Current Trials
> Lab Bench to Bedside
> Current Trials
> Referral Process
> Clinical Partners
> Research Partners
> Community Partners
> Financial Counseling
The UC Barrett Cancer Institute at University Hospital is hosting a phase-1 clinical trial sponsored by the UC Early Stage Drug Development Program and the UC College of Medicine. Led by Olivier Rixe, MD, PhD, the center offers discovery-driven new cancer treatment options only available in an experimental (phase-1) clinical trial setting.
The first step in moving tested scientific concepts from the laboratory bench to bedside, phase-1 trials are intended to evaluate safe dosages, method of administration (oral or injection) and frequency. Trials typically include less than 50 people and therapy is administered in a hospital setting where the patient can be monitored 24/7 by the attending physicians and support staff.
Trials are available for patients with advanced, solid cancerous tumors that have failed standard medical therapies. Protocols are evaluated by the Internal Review Board for scientific content, safety and ethical considerations prior to implementation and throughout the trial’s conclusion.
The UC Early Drug Development Program is part of the Cincinnati Cancer Consortium, a joint cancer program involving the UC College of Medicine, Cincinnati Children’s Hospital Medical Center and UC Health University Hospital. The collaborative initiative brings together interdisciplinary research teams of caring scientists and health professionals to research and develop new cures, while providing a continuum of care for children, adults and families with cancer.
Current Trials 
A Dose-Escalation, Single Arm, Combination Study of Cabazitaxel with Gemcitabine to Determine the Safety and Pharmacokinetics in Subjects with Advanced Solid Malignancies- sponsored by Sanofi Aventis (IRB approval is pending++++++++)
> Current UC Barrett Cancer Center clinical trials
Referral Process
For information on referring a patient to the phase-1 clinical trials unit, call 513-584-7698 or toll free at 866-724-CURE.
Clinical Partners
UC Health University Hospital
- Three-bed dedicated inpatient hematology oncology care unit for administration of phase-1 clinical trial therapies
- 24/7 medical coverage by board-certified oncology physicians and experienced nursing staff
- Dedicated symptom management clinic as well as on-site nutrition, pastoral and rehabilitation services
- Advanced on-site imaging services, including dynamic computed tomography (CT), dynamic contrast-enhanced magnetic resonance imaging and combination positron emission testing/CT scans
UC Barrett Cancer Institute at University Hospital
- Outpatient care facility for short- and long-term follow-up clinical care located on the UC Academic Health Center medical campus near downtown
- Access to sophisticated radiation oncology treatment systems, including 3D and IMRT image-guided radiation therapy, and on-site private chemotherapy units
Research Partners
The scientific content of each research protocol is based on interactive collaboration with diverse basic scientists from the UC’s cancer and cell biology department, located at the Vontz Center for Molecular Studies, as well as scientists with UC’s Metabolic Diseases Institute, UC’s Center for Imaging Research and other laboratories based in other UC laboratories, including molecular genetics, biochemistry and microbiology. A specific focus is given to the development of new biomarkers and cognitive analysis to determine individualized therapies.
Community Partners
American Cancer Society, Cincinnati Hope Lodge
The Musekamp Cincinnati Hope Lodge offers a cost-free comfortable, home-like environment for cancer patients traveling to Cincinnati for care. Adults with cancer may arrange for themselves and up to two caregivers to stay at the Hope Lodge through a referral process involving their Cincinnati-area physician, social worker or nurse. The lodge provides:
- Kitchen areas where families can cook their own meals,
- Comfortable rooms with private bathrooms and space for both cancer patients and their caregivers, and
- An on-site chapel, exercise room and library
Financial Counseling
For questions about billing and insurance related to phase-1 clinical trial care, Tanya Green the UC Barrett Cancer Institute at University Hospital at 513-584-3464.
